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Ongoing Research

The Veterinary Genetics Laboratory at N.C. State’s Veterinary Health Complex has ongoing research programs available for the following breeds and conditions:

Cardiac- Canine

(Click here for Cardiac-Feline)

Subvalvular aortic stenosis (SAS) Study Subvalvular aortic stenosis, also referred to as SAS, is a common heart defect in dogs, especially in Golden Retrievers, Newfoundlands, and Rottweilers. Dogs with severe disease may develop fainting, rear limb weakness, or fluid in the lungs (heart failure). Heart failure can cause coughing, rapid breathing, or shortness of breath. Select your breed for more information and forms to participate in studies:

Dilated cardiomyopathy Dilated cardiomyopathy is an adult onset heart muscle disease that can lead to sudden death or the development of congestive heart failure where the dog starts to cough or becomes short of breath. Predisposed breeds include the Great Dane and Doberman Pincher. In these breeds, DCM can be inherited in family lines. Select your breed for more information and forms to participate in studies:

Ocular- Canine

Dr. Keith Montgomery and the Genetic Laboratory at North Carolina State University College of Veterinary Medicine are performing research studies to identify the gene mutations responsible for corneal diseases in dogs.

Select your breed for more information and forms to participate in studies:

Immune System- Canine

Immune-Mediated Hemolytic Anemia (IMHA) Study
Dr. Steven Friedenberg and the Veterinary Genetics Laboratory at North Carolina State University College of Veterinary Medicine are working to identify the gene mutations responsible for the development of IMHA. Requirements to participate in this study include:
  • Dogs of any age that have been diagnosed with immune-mediate hemolytic anemia.
  • We are particularly interested in Cocker Spaniels, Shih Tzus, and Malteses, but this is not a requirement!
  • It is NOT necessary for your dog to have active signs of the IMHA, as long as he or she has been diagnosed with IMHA in the past.

For full details about this study go to the IMHA site here.

Standard Poodles – Addison’s Disease
Dr. Katharine Lunn and the Veterinary Genetics Laboratory at North Carolina State University College of Veterinary Medicine are working to identify the gene mutations responsible for the development of Addison’s disease in Standard Poodles. Requirements for new participants for this study include:
  • Standard Poodles of any age that have already been diagnosed with Addison’s disease
  • Standard Poodles greater than 10 years of age who do NOT have Addison’s Disease, with laboratory tests confirming the absence of the disease

For full details about this study go to the Addison study site here.

Cardiac- Feline


Feline Hypertrophic Cardiomyopathy Hypertrophic cardiomyopathy (HCM) is a condition characterised by the inward thickening of the heart muscle, resulting in a reduction of chamber volume, thereby reducing the volume of blood that the heart can pump with each contraction. It is believed that HCM in cats could be genetic. Recently, genetic mutations have been identified in both the Maine Coon and Ragdoll breeds of cat, and there is ongoing work looking for further mutations in the Birman, Bengal Cat and Sphynx breeds.
Select your breed for more information and forms to participate in studies:
Blood samples:
1-3 mls of blood in an EDTA tube may be submitted. The sample does not need to be refrigerated during shipment, it is very stable once in the EDTA tube. Please double bag or put in secondary container to avoid breakage and spills.

Sample may be shipped to:
NCSU – College of Veterinary Medicine
ATTN: Veterinary Genetics Laboratory
Research Bldg. 228
1060 William Moore Dr.
Raleigh, NC 27607

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NCSU Veterinary Health Complex
1052 William Moore Dr.
Raleigh, NC 27607
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